Charles Darwin

"The love for all living creatures is the most noble attribute of man." Charles Darwin

Monday, November 17, 2014

The Anti-microbial Age





Advertisement for Pears' Soap, 1889
How
 did we survive before antibacterial soaps and hand sanitizers? 

Or is it that things have changed?

Did it happen that there were suddenly more harmful bacteria out there and we needed to better arm ourselves? 

Or perhaps plain old soap was indeed adequate and we were not deemed competent enough to use it correctly? 

Why is what was good enough, not good enough anymore? 

Why does it seem these days we are so very inclined to take everything to such extremes? Is it all really necessary? 

Did I miss the cataclysmic bio-incident which precipitated the advent and saturation of these products onto the market? I'm trying to think back ... was it SARS? I can't remember. What I mean is, I can remember before and I can remember after, but I can’t remember why, as in, what it was that sparked the change?

Vaccinations aside (for the sake of this conversation), my germ-filled childhood saw me armed with little more than a bar soap and a facecloth; and yet I came through it relatively unscathed, save for the odd ear infection - which, in my particular case I can say with a fair degree of certainty no amount of antibacterial soap or hand sanitizer would have curtailed.

And it’s not even just the rapidly adapting microbes and increase in allergies that’s concerning, it’s what we’re doing to our immune systems with this obsessive hyper-sterilization. 

I understand precautions being taken in hospitals and around those with compromised immune systems. But healthy individuals in everyday life? Would we not be better served by making it socially acceptable to put a face mask on when we get a bug? 

Furthermore, should young people not be building up their immune systems by some degree of exposure to microbes? Is that not a good thing? Is that not how we develop new antibodies? Crikey, when I was a kid I use to chew ABC gum; and my sister, she ate worms. And you know what? We both lived to tell.


Soap 

The earliest recorded evidence of the production of soap-like materials dates back to around 2800 BC in ancient Babylon. [1]

When used for cleaning, soap allows insoluble particles to aggregate inside micelles - tiny spheres formed from soap molecules. Through this action, the hydrophobic particles of oil and fat can then be rinsed away. Wikipedia

Structure of a micelle, The exterior is hydrophilic (attracted to water)
 and the interior is lipophilic (attracted to oils).


Industrially manufactured bar soaps first became available in the late 18th century, as advertising campaigns in Europe and the United States promoted popular awareness of the relationship between cleanliness and health.[2]


Hand Sanitizer 

According to a document [3] released by the University of Minnesota Center for Infectious Disease Research and Policy:

"Studies have shown that influenza viruses can survive on environmental surfaces and can infect a person for up to 2 to 8 hours after being deposited on an environmental surface."


Hand alcohol in a hospital
90% alcohol rubs are more effective against viruses than most other forms of hand washing, but highly flammable and irritating on skin with prolonged use.[4]

Isopropyl alcohol will kill 99.99 percent or more of all non-spore forming bacteria in less than 30 seconds, both in the laboratory and on human skin.[5][6]

A controlled study of 200 workers at FedEx in 2004 showed that placing hand sanitizer dispensers in an office and educating workers about their use resulted in a 21% reduction in absenteeism.[7] Controlled studies showed an even greater reduction in absenteeism (51%) in elementary schools [8] and college dormitories (43%). [9]

No mechanism for resistance to alcohol has ever been described in bacteria. [10]

According to the American Association of Poison Control Centers, there were nearly 12,000 cases of hand sanitizer ingestion in 2006. [11]

Although allergy to alcohol-only rubs is rare, additives like fragrances and preservatives can cause contact allergies. [12] These other ingredients do not evaporate like alcohol and accumulate leaving a sticky residue until they are removed with soap and water.


Antibacterial Soap

Antibacterial soap is any cleaning product to which active antimicrobial ingredients have been added. These chemicals kill microbes, but are no more effective at deactivating viruses than any other kind of soap or detergent, and they also [indiscriminately] kill non-pathogenic bacteria.[13]

From its initial use as an antimicrobial agent in hospital scrub in the 1970's, triclosan (C12H7Cl3O2) has expanded commercially and is now added to consumer products like soaps, shampoos, deodorants, toothpastes, mouth washes and cleaning  supplies.[14] As well as kitchen utensils, toys, bedding, socks and trash bags.[15][16]

Some studies show that antimicrobial hand soaps containing triclosan provide a slightly greater bacterial reduction on the hands compared to plain soap, and yet others show no difference.[17] For example, researchers at Dial found that the transfer of bacteria to objects was reduced following washing with antimicrobial hand soap containing triclosan compared to regular soap.[18] While according to the FDA, antimicrobial soaps containing triclosan have not been shown to possess additional benefits over conventional soap and water.[19] Furthermore, the FDA has found  no evidence to indicate that triclosan in personal care products provides extra benefits to health beyond its anti-gingivitis effect in toothpaste*.[20] 

*A systematic review of randomized controlled trials found that triclosan-containing toothpastes are marginally beneficial in reduction of tooth cavities and reduce dental plaque, gingival inflammation and gingival bleeding.[21]

A 2010 study found that children who had higher exposure to triclosan had a higher incidence of hay fever.[21] 

Triclosan has also been associated with a higher risk of food allergies.[22] 

Other studies have linked triclosan to allergic contact dermatitis in some individuals.[23][24]

In August 2009, the Canadian Medical Association asked the Canadian government to ban triclosan use in household products over concerns of creating bacterial resistance and producing dangerous side products (chloroform).[25]

In an article entitled, "It's Probably Best to Avoid Antibacterial Soaps," published at www.theatlantic.com, the author refers to a study in which the urine of 180 pregnant women, and the cord blood of newborn infants were tested for the presence of antimicrobial chemicals: 

"... Researchers from Arizona State University and State University of New York’s Downstate School of Public Health found triclosan in 100 percent of the women’s urine samples, and triclocarban in 87 percent of the samples. Of the 33 cord blood samples they looked at, 46 percent contained triclosan and 23 percent contained triclocarban."[26]

In rats, exposure to very high levels of triclosan has been associated with lower levels of thyroid hormone and testosterone.[27][28]

Triclosan has been reported to impair the conversion of electrical stimulus to mechanical response in the cardiac and skeletal muscle of mice.[29]

Studies show that substantial quantities of triclosan (170,000 – 970,000 kg/yr.) can break through waste-water treatment plants and damage algae on surface waters.[30]

Triclosan has been found both in the bile of fish living downstream from waste-water processing facilities and in human milk.[31]

Triclosan is toxic to aquatic bacteria at levels found in the environment. It is highly toxic to various types of algae and has the potential to affect the structure of algal communities, particularly immediately downstream of effluents from waste-water treatment facilities that treat household waste-waters.[32]

A comprehensive analysis from the University Of Michigan School Of Public Health indicated that plain soaps are just as effective as consumer-grade antibacterial soaps with triclosan in preventing illness and removing bacteria from the hands. [33]

On December 17, 2013, the FDA issued a draft rule revoking the ‘Generally Regarded as Safe’ status of triclosan as an ingredient in hand wash products, citing the need for additional studies of its potential endocrine and developmental effects; impact on bacterial resistance; and carcinogenic potential.[34]

On May 16, 2014, Minnesota signed a bill banning the use of triclosan in most retail consumer hygiene products sold in the state. The ban is set to take effect January 1, 2017.[35]

Health Canada has concluded from it's assessment that:
 "...triclosan is not harmful to human health, but in significant amounts can cause harm to the environment." 
(Though how those two things can be mutually exclusive is beyond me.)


The take away from all this:

Wash your hands with soap and water. Don’t touch your face with your hands- EVER. Respect personal space. Wear a face-mask if you have the flu. Try to avoid products containing triclosan. And if you feel inclined to beef-up your microbial protection, choose an alcohol based hand sanitizer; though if statistics are any indication, perhaps it bears reminding that such products are intended for external use only. And as an aside, if you are ever prescribed antibiotics for what ails you, please, please, please do your fellow humans a favor and finish your prescription.






Updates/Related

Skip the Anti-Bacterial Soap: Regular Suds Work Just as Well / LiveScience / September 15, 2015



REFERENCES

[1] How to make handmade vegetable soap May 23, 2014, from http://howikis.com/Make_Handmade_Vegetable_Soap
[2] Nef 1936:653, 660.
[3] "Novel H1N1 Influenza (Swine Flu) Overview". Center for Infectious Disease Research and Policy. 
[4] Rotter M. (1999). "Hand washing and hand disinfection". Hospital epidemiology and infection control 87.
[6] Hibbard, John S. (May–June 2005). "Analyses Comparing the Antimicrobial Activity and Safety of Current Antiseptic Agents". J. Infusion Nursing (Infusion Nurses Society) 28 (3): 194–207.doi:10.1097/00129804-200505000-00008PMID 15912075.
[7] Arbogast, Ferrazzano-Yaussy, Cartner (2004). "FedEx Custom Critical Outcome Study Executive Update, Interim Report". GOJO Industries, Inc.
[8] Guinan, M., M. McGuckin, and Y. Ali., M; McGuckin, M; Ali, Y (2002). "The effect of a comprehensive handwashing education program on absenteeism in elementary schools". American Journal of Infection Control 30 (4): 217–220. doi:10.1067/mic.2002.120366PMID 12032496.
[9] White, C., R. Kolble, R. Carlson, N. Lipson, M. Dolan, Y. Ali, M. Cline, Cindy; Kolble, Robin; Carlson, Rebecca; Lipson, Natasha; Dolan, Mike; Ali, Yusuf; Cline, Mojee (2003). "The effect of hand hygiene on illness rate among students in university residence halls". American Journal of Infection Control 13 (6): 364–370. doi:10.1016/S0196-6553(03)00041-5.
[10] Dix, Kathy (December 1, 2002). "CDC's Endorsement of Alcohol Hand Rubs Launches New Era in Hand Hygiene". Infection Control Today.
[11] "Paging Dr. Gupta, Hand sanitizer risks". CNN. June 21, 2007.
[12] de Groot AC (1987). "Contact allergy to cosmetics: causative ingredients". Contact Dermatitis. 17:26--34 (1): 26–34. doi:10.1111/j.1600-0536.1987.tb02640.xPMID 3652687.
[14] Thompson A, Griffin P, Stuetz R, Cartmell E; Griffin; Stuetz; Cartmell (2005). "The fate and removal of triclosan during wastewater treatment". Water Environ. Res. 77 (1): 63–7.doi:10.2175/106143005X41636JSTOR 25045839PMID 15765937.
[15] Record in the Household Products Database of NLM
[16] Crinnion, WJ; Griffin, P.; Stuetz, R.; Cartmell, E. (2005). "The CDC Fourth National Report on Human Exposure to Environmental Chemicals: what it Tells Us about our Toxic Burden and How it Assists Environmental Medicine Physicians". Water Environ. Res. 77(1): 63–7. doi:10.2175/106143005X41636JSTOR 25045839PMID 15765937.
[17] Montville, Rebecca; Schaffner, Donald W. (1 November 2011). "A Meta-Analysis of the Published Literature on the Effectiveness of Antimicrobial Soaps". Journal of Food Protection 74 (11): 1875–1882. doi:10.4315/0362-028X.JFP-11-122PMID 22054188.
[18] Fuls, Janice L.; Rodgers ND; et al. (April 2008). "Alternative Hand Contamination Technique To Compare the Activities of Antimicrobial and Nonantimicrobial Soaps under Different Test Conditions". Applied and Environmental Microbiology 74 (12): 3739–3744.doi:10.1128/AEM.02405-07PMC 2446551PMID 18441107.
[19]"Triclosan: What Consumers Should Know". Fda.gov. 2013-12-16. Retrieved 2014-07-15.
"Triclosan: What Consumers Should Know". U S Food and Drug Administration. 8 April 2010. Retrieved 13 April 2010.
[20] Philip Riley and Thomas Lamont. (December 2013). "Triclosan/copolymer containing toothpastes for oral health". Cochrane Database of Systematic Reviews 12 (CD010514): CD010514. doi:10.1002/14651858.CD010514.pub2PMID 24310847.
[21] Clayton EM, Todd M, Dowd JB, Aiello AE; Todd; Dowd; Aiello (March 2011). "The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006". Environ. Health Perspect. 119 (3): 390–6.doi:10.1289/ehp.1002883PMC 3060004PMID 21062687Lay summary –ScienceDaily (Nov 30, 2010).
[22] Sicherer, SH; Leung, DY (January 2013). "Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012". Journal of Allergy and Clinical Immunology 131 (1): 55–66. doi:10.1016/j.jaci.2012.11.007PMID 23199604.
[23] Bhutani T, Jacob SE; Jacob (May 2009). "Triclosan: a potential allergen in suture-line allergic contact dermatitis". Dermatol Surg 35 (5): 888–9. doi:10.1111/j.1524-4725.2009.01151.xPMID 19389086.
[24] Campbell L, Zirwas MJ; Zirwas (December 2006). "Triclosan". Dermatitis 17 (4): 204–7.doi:10.2310/6620.2006.06014PMID 17150172.
[25] Bedoux, Gilles; Roig, Benoit; Thomas, Olivier; Dupont, Virginie; Le Bot, Barbara (2011)."Occurrence and toxicity of antimicrobial triclosan and by-products in the environment - Springer". Environmental Science and Pollution Research 19 (4): 1044–65.doi:10.1007/s11356-011-0632-zPMID 22057832.
[26] http://www.theatlantic.com/health/archive/2014/08/its-probably-best-to-avoid-antibacterial-soaps/375899/
[27] Witorsch RJ (July 2014). "Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products". Crit. Rev. Toxicol. 44 (6): 535–55. doi:10.3109/10408444.2014.910754PMID 24897554.
[28] Crofton, Kevin M., et al. [http://www.sciencedirect.com/science/article/pii/S1382668907000683 "Short-term in vivo'' exposure to the water contaminant triclosan: Evidence for disruption of thyroxine."Environmental Toxicology and Pharmacology 24.2 (2007): 194-197.
[29] Cherednichenko G, Zhang R, Bannister RA et al. (August 2012). "Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle". Proc. Natl. Acad. Sci. U.S.A. 109 (35): 14158–63. Bibcode:2012PNAS..10914158C.doi:10.1073/pnas.1211314109PMC 3435154PMID 22891308.
[30] Halden, Rolf U. (2014). "On the Need and Speed of Regulating Triclosan and Triclocarban in the United States". Environmental Science & Technology 48 (7): 3603.doi:10.1021/es500495p.
[31] Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J; Pettersson; Parkkonen; Sturve (March 2002). "Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden". Chemosphere 46 (9–10): 1485–9. doi:10.1016/S0045-6535(01)00255-7PMID 12002480.
[35] STEVE KARNOWSKI (2014-05-20). "Minnesota Becomes First State To Ban Antibacterial Chemical Triclosan From Soaps". Huffingtonpost.com. 



ADDITIONAL RESOURCES

http://en.wikipedia.org/wiki/Triclosan
Triclosan and Antibiotics resistance summary by GreenFacts of an opinion by the European Commission Scientific Committee on Consumer Safety (March 2010)
"Is antibacterial soap any better than regular soap?"  01 August 2001.  HowStuffWorks.com. <http://health.howstuffworks.com/skin-care/cleansing/myths/question692.htm>  15 November 2014.
http://www.theatlantic.com/health/archive/2014/08/its-probably-best-to-avoid-antibacterial-soaps/375899/



IMAGE CREDITS

"Pears'Soap" by uncredited commercial artist - Macmillan's Magazine, p. 49. Licensed under Public domain via Wikimedia Commons - http://commons.wikimedia.org/wiki/File:Pears%27Soap.jpg#mediaviewer/File:Pears%27Soap.jpg

"MicelleColor" by Smokefoot, original by Mariana Ruiz Villarreal, LadyofHats - cut from Media:Phospholipids aqueous solution structures.svg. Licensed under Public domain via Wikimedia Commons - http://commons.wikimedia.org/wiki/File:MicelleColor.png#mediaviewer/File:MicelleColor.png

"Handsprit" by Entheta - Own work. Licensed under Creative Commons Attribution-Share Alike 3.0 via Wikimedia Commons - http://commons.wikimedia.org/wiki/File:Handsprit.jpg#mediaviewer/File:Handsprit.jpg





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